Matt Ryan (Boston College) and the Falcons are facing a 1-3 start that he's not had to deal with before, so he will need to lead the team out of the hole.
After hurting his ankle over the weekend, C.J. Spiller (Clemson) practiced with the Bills Tuesday, so his chances seem good that he can keep playing.
Texans' WR DeAndre Hopkins (Clemson) is heading into his matchup with Richard Sherman confidently. Mel Kiper has Hopkins ranked as the top rookie in the NFL so far.
Even though Anquan Boldin (Florida State) has made some waves for the 49ers so far, his former team - the Ravens - might actually be missing TE Ed Dickson more than Boldin.
Graham Gano (Florida State), the Carolina Panthers kicker, feeds off of the success of the punter, Brad Nortman. It's incredible that with Gano, Sebastian Janikowski and Dustin Hopkins, the Seminoles have three kickers in the NFL.
If he can go, Christian Ponder (Florida State) will be the starting quarterback for the Vikings.
Calvin Johnson (Georgia Tech) is obviously the most talented player on the Detroit Lions, but Reggie Bush might be the most valuable player on the team right now.
Another former Tech WR, Stephen Hill (Georgia Tech), suffered a concussion in last week's game.
Pittsburgh RB Jonathan Dwyer (Georgia Tech) has been fined $21,000 for using the crown of his helmet to hit a defender.
In a pretty creative announcement, Torrey Smith (Maryland) announced he's expecting a child.
It's always sad to see when athletes are a shell of their former selves. That might be the case with LB Jon Beason (Miami) right now. Could he be at the end of his career?
Jimmy Graham (Miami), who has been killing it all year, had another pretty awesome catch for a touchdown on Monday night.
Texans WR Andre Johnson (Miami) hasn't been having a good season, but he says he doesn't really care about the boos coming his way.
Willis McGahee (Miami), a new additions to the Browns, isn't Trent Richardson, but he's still there to try and replace some of what the Browns lost.
Big defensive tackle Vince Wilfork (Miami) is probably out for the year after he tore his Achilles.
If you've got Gio Bernard (North Carolina) on your fantasy team, you should really give him a solid look at starting.
After giving up some big plays, the Cowboys benched LB Bruce Carter (North Carolina) for much of the second half.
Patrick Peterson did his part to help ruin the first start for QB Mike Glennon (N.C. State) and the Buccaneers.
This writer doesn't think Philip Rivers (N.C. State) is back yet. He's playing better than he ever has.
After really looking to get Larry Fitzgerald (Pittsburgh) the ball in the second half, the Cardinals reaped the benefits as they ended up pulling out the win.
LeSean McCoy (Pittsburgh) is still the top fantasy running back after this week. He has been having an absolutely great year so far.
After tearing his quad, Dwight Freeney (Syracuse) will be out for the year for the Chargers.
This Houston restaurant is offering the "Matt Schaub" (Virginia) burger where you "pick six" toppings and then "pay dearly" for it. Ouch. Someone's bitter. Either way, Schaub's time in Houston might be coming to a close.
Michael Vick (Virginia Tech) says he likes the sense of urgency that he feels with the team.
With the Giants cutting RB Da'Rel Scott, they could actually be growing in confidence with David Wilson (Virginia Tech), and he might be seeing an expanded role.